Peripheral catheter directed thrombolysis (CDT) with alteplase Clinical Guideline
Version No 1.1, approved 20 March 2023
Alteplase is a thrombolytic medication used for the dissolution of arterial or venous, thrombus or emboli. Peripheral catheter directed thrombolysis (CDT) is a procedure used to deliver the thrombolytic directly to the location of the thrombus/embolus.
Background
The Peripheral catheter directed thrombolysis (CDT) with alteplase Clinical Guideline (PDF 511KB) has been developed jointly by the Vascular Surgery Departments of SALHN and CALHN to assist in the safe administration and management of alteplase during peripheral catheter directed thrombolysis.
The use of alteplase for catheter directed thrombolysis is an ‘off-label’ indication. The following guideline has been developed based on primary literature, published guidelines, expert opinion and clinical experience.